The site provides coverage to MediaCityUK -- a property development with tenants like the BBC, ITV Granada and the University of Salford -- and the surrounding area.
Previously, UK 5G tests have only encompassed a single location or used parts of the 4G network, Vodafone noted.
Watch this: What the heck is a 5G network?
"We are leading the rollout of 5G across the UK, starting with Greater Manchester. A further six cities –- Birmingham, Bristol, Cardiff, Glasgow, Liverpool and London –- will shortly receive full 5G too," said Vodafone UK Chief Executive Nick Jeffery in a statement.
Next year, the company plans to bring 5G to the Scottish Highlands, Cornwall, the Lake District and other locations.
Back in March, the British government announced the winners of a £25 million competition to test 5G technologies across the UK, with the funds divided among projects based on using the connectivity for rural communities, tourism, health care, agriculture, manufacturing and self-driving cars.