Felony charges filed in fatal Tesla Autopilot crash Gaspard Ulliel ski accident Amazon opening a brick-and-mortar clothing store Free COVID-19 test kits US to give out 400 million N95 masks Wordle explained

What to know about 'mixing and matching' COVID vaccines and booster recommendations

Now, people who got Moderna's or Pfizer's vaccine only need to wait five months to get a booster instead of six.

Aleksandr Zubkov/Getty Images
For the most up-to-date news and information about the coronavirus pandemic, visit the WHO and CDC websites.

While the definition of "fully vaccinated" hasn't changed, you're not considered "up to date" by the US Centers for Disease Control and Prevention until you've gotten your COVID-19 booster shot (when you're eligible for it). That's because increasing evidence shows boosters are needed to restore protection against the new omicron variant, which has reduced the vaccines' effectiveness against COVID-19 infection. Omicron is also leading to more cases of reinfection, or people getting COVID-19 twice

Everyone aged 12 and older is eligible for a booster. Recently, the CDC even shortened the period of time someone who got Pfizer's or Moderna's vaccine needs to wait for a booster, down to five months instead of six. (People who got Johnson & Johnson's vaccine should still get a booster at least two months after their one-dose vaccine.) 

The booster recommendation is clear now (get one), but the guidance leaves a little choice up to you. While the CDC has recommended that everyone receive a booster dose of Pfizer's or Moderna's vaccine (either mRNA vaccine is preferred over Johnson & Johnson's in most cases, the CDC says, even if you originally got the J&J). That's because people are now able to "mix and match" COVID-19 vaccines after heterologous booster doses were authorized by the US Food and Drug Administration.

The booster rollout in the US has been a controversial one. Some health officials have called on countries such as the US and Israel to stop giving extra doses to healthy people while as few as 9.5% of people in low-income countries have had one shot of a COVID-19 vaccine, according to Our World in Data. There is also another vaccine developed by the US Army currently being tested, which researchers hope will offer a broader range of protection against COVID-19 from all variants, including new ones. The results of the clinical trials aren't available yet, though. 

While the world continues to watch the coronavirus and scientists adjust information accordingly, here's what to know about choosing a booster. 

How are the COVID-19 vaccines different? 

While all three vaccines have the same effect -- protection against severe COVID-19 disease -- the way they function is a little different. Pfizer and Moderna are mRNA vaccines, which teach our cells to make a specific protein and build immunity against a virus. Johnson & Johnson (the only authorized one-dose vaccine) is a viral vector, which uses a harmless virus to activate an immune response that teachers our bodies what to fight in future infections.

Both vaccine types prepare our immune systems for COVID-19 infection and none of the coronavirus vaccines infects us with the actual coronavirus. Pfizer's and Johnson & Johnson's booster are the same dose as the original vaccines, while Moderna's booster is half the size of its original vaccine. 

After an outside committee that advises the CDC raised concerns over a rare but sometimes fatal blood-clotting disorder that can happen following vaccination with Johnson & Johnson's vaccine, the CDC recommends people receive Pfizer's or Moderna's vaccine or booster instead. However, Johnson & Johnson's vaccine is still authorized and available for people age 18 and up if they prefer it. 

Does mixing and matching work?

Research available now in the US as well as other countries shows that choosing a different COVID-19 vaccine as a booster is effective. In some cases, mixing and matching seems to produce a stronger response compared with sticking to the original vaccine. 

During a mix-and-match COVID-19 vaccine trial funded by the National Institute of Allergy and Infectious Diseases (before omicron was the dominant variant), boosters from all three vaccine companies induced good immune responses in roughly 450 people who got different vaccines. In the study, Moderna's booster gave the most robust response. However, that study examined a full dose of Moderna, rather than the authorized half-dose of the company's booster, which could minimize Moderna's edge over Pfizer, as The Atlantic reported. 

Another preliminary study of 64 people found that people who originally received Pfizer's vaccine, but then got a booster of Johnson & Johnson's vaccine, had a stronger response to Johnson & Johnson's vaccine. This included the harder-to-measure T-cell immune responses Johnson & Johnson's vaccine appears to protect with as opposed to antibody response alone -- which Johnson & Johnson said may be the reason two doses of its vaccine give great protection against hospitalization and disease caused by the omicron variant.  

An earlier study from Spain published in the Nature journal in May 2021 found that mixing one dose of AstraZeneca (a similar vaccine to Johnson & Johnson's) with one dose of Pfizer produces a higher antibody response than people who receive two doses of AstraZeneca. It isn't clear whether this group had a higher immune response than people who received two doses of Pfizer, however. 


The definition of "fully vaccinated" hasn't changed. A person is considered fully vaccinated two weeks after their second dose of Pfizer or Moderna, or two weeks after a single dose of Johnson & Johnson. 

Sarah Tew/CNET

Which booster shot should I get? 

No matter which COVID-19 vaccine you originally got (Pfizer, Moderna or Johnson & Johnson), you should get a booster of Moderna's or Pfizer's vaccine, the CDC says. Kids and teens ages 12 to 17 should get a Pfizer booster, however, because Pfizer is the only COVID-19 vaccine authorized for people under age 18. 

The preference for either mRNA vaccine followed concerns of a rare but serious blood-clotting disorder associated with Johnson & Johnson's vaccine, called thrombosis with thrombocytopenia syndrome. Since the CDC paused the distribution of the disorder to investigate, more information revealed that it's less rare than previously understood and occurs in both men and women. (Although still rare over all, occurring in 57 cases out of 16.9 million doses of Johnson & Johnson given, per the CDC, women ages 30 to 49 are at higher risk of the disorder with about 1 out of 100,000 women experiencing it). Nine people have died from TTS and all cases required hospitalization or ICU admission, according to a CDC presentation

Johnson & Johnson's vaccine is available to you if you prefer it for any reason, or if you can't take Moderna's or Pfizer's because of an allergy. But given the excellent safety and wide availability of Pfizer's and Moderna's vaccine, the CDC made the recommendation in line with that other countries have done for AstraZeneca's vaccine, which is associated with the same rare issue. 

study published by the CDC in September (before omicron) compared vaccine effectiveness in the real world found that two doses of Moderna's vaccine was 93% effective at preventing hospitalization, two doses of Pfizer were 88% effective and one dose of Johnson & Johnson was 71% effective. And while omicron does evade our protection against COVID-19 infection given by the vaccines, some protection against severe disease remains

According to data on booster doses collected by the CDC, most people who got Pfizer's or Moderna's vaccine seem to stick to their original vaccine brand (most people who got Johnson & Johnson's vaccine originally have gotten a different booster). However, millions of Americans have opted for a different vaccine brand as a booster, and no safety concerns have been raised by either the FDA or CDC in people who've mixed and matched. 

Are you fully vaccinated after your booster? 

Importantly, the definition of fully vaccinated hasn't changed (though it might in the future). You're still fully vaccinated two weeks after your second Pfizer or Moderna shot or two weeks after your Johnson & Johnson vaccine. Whether someone has received a booster doesn't affect their "fully vaccinated" status. 

Can I mix and match the first two shots?

No, the CDC's statement on mixing COVID-19 vaccines only applies to boosters. As of now, the FDA has only authorized a mixed-series booster, meaning the first coronavirus vaccine series must be one dose of Johnson & Johnson or two doses of Moderna or Pfizer. 

Once the mixed-series boosters start rolling out to Americans in greater numbers, there will be more data on the safety and effectiveness of a mixed COVID-19 series. Although it might be too early to hope, this might mean that data on mixing for boosters will inform decisions on primary coronavirus vaccine series being used together, making it easier to reach underserved communities, and possibly reducing health care and vaccine inequity.

The information contained in this article is for educational and informational purposes only and is not intended as health or medical advice. Always consult a physician or other qualified health provider regarding any questions you may have about a medical condition or health objectives.