The best results from the S220 come at ISO 80 and ISO 100. As soon as you go up to ISO 200, detail and sharpness are on steady decline. The marks on the ruler are barely visible from noise reduction at ISO 400. Unfortunately, the camera seems to love this sensitivity when its in Auto ISO.
There are three remaining sensitivities above ISO 400--800, 1,600, and 2,000--that are really not usable for prints. However, if you're in low or dark lighting, you'll be able to capture photos. Just don't look at them too closely.
Shot using the Landscape scene mode, the S220 went with ISO 400 likely because of the dark background. More importantly, if you were to print the photo at the center full size at 9x12, you would see a lot of problems: blown-out highlights, purple/blue fringing, and mushy, smeary details that make the result look more like a painting than a photo.
All of that said, when printed at a typical size like 4x6 inches, the only thing immediately noticeable are the blown highlights and a general lack of sharpness--neither uncommon for low-end point-and-shoot cameras.