The T2i's control layout is almost identical to the T1i's; however, Canon has redesigned many of the buttons--they're flatter, and a tad harder to feel. Now there's a dedicated button for jumping into the Quick Control panel. Other than that, the control layout is the same as it's been for many generations, and the layout pretty much works. However, I'd really rather have the ISO button in place of the Picture Styles rather than it being on top of the camera--that's where most point-and-shoot upgraders would expect it to be, and would consolidate all the shooting controls in one spot.
I'll make the same complaints I brought up with the T1i: no custom settings and poor placement of the movie mode. The latter is really cumbersome, in part because the dial doesn't spin 360 degrees, so jumping between movies and still shooting modes is really annoying.