Watch How Scientists Can 3D-Print Human Heart Tissue
Watch How Scientists Can 3D-Print Human Heart Tissue
4:04

Watch How Scientists Can 3D-Print Human Heart Tissue

Science
Speaker 1: Nearly one in a hundred US kids are born with a heart defect. That's why scientists in this Stanford lab are working on an innovative new technique to 3D print heart tissue that could give those kids longer and healthier lives. 3D printers are changing the way we build just about everything from our cars to our homes, even our food. But can they recreate [00:00:30] one of the most crucial and complex human organs? Speaker 2: It sounds ambitious. It is ambitious, but, uh, we believe that a lot of the basic building blocks to go ahead and start a project like this, uh, in place, Speaker 1: Dr. Mark Skylar Scott and his team of bioengineers are using advanced 3D printing techniques to turn a paste made of living cells into actual heart tissue. The goal to one day be able to print crucial pieces of the heart like valves and ventricles [00:01:00] that are living and can actually grow with a patient. Speaker 2: For adults, we have donor organs that can last 20, 30 years after transplantation, which if you're a 60 or 70 year old, adult is almost as good as a cure. But if you're a child at the age of two, needing a transplant, knowing that after 20, 30 years your transplant may be rejected, uh, by, by an immune reaction, uh, then this is not long enough. Speaker 1: The concept of printing living tissue isn't new. It's called bioprinting, [00:01:30] but it can be a slow process. Speaker 2: If you truly want to recapitulate everything about an organ, one might think about the need to write every single cell in its final location. Now, if you did that at a rate of about a thousand cells per second, it would take over a thousand years to make a single hop, Speaker 1: And that's where Dr. Skylar Scott's team made a breakthrough. They developed a way to print with clusters of thousands of cells called organoids. Speaker 2: We take millions of those aggregates [00:02:00] and condense those into what is essentially like a, a human stem cell mayonnaise, uh, that we can then print through the printer. We can write very large and thick slabs of tissue that can really be used for transplantation in the future. Speaker 1: Yes, he just said stem cell mayonnaise, and once it's printed, it takes on a general shape of tissue that they can print blood vessel networks into. Speaker 2: We have the ability to write tissue living cells from [00:02:30] stem cells and be able to come in and pattern vascular channels in 3D and then connect those channels to a pump and flow oxygen and nutrients through that tissue so it actually stays alive. Speaker 1: What you're seeing in these videos is that technique simulated for us with what the team described as essentially hair gel. The stem cells they use when they're printing a real sample are grown here in this large bioreactor. All those little things you see that look like [00:03:00] bubbles are actual stem cells. So far, the team has been able to create a structure similar to a human vein, about two inches long and half a centimeter in diameter that could actually pump fluid on its own. They couldn't show it to us because they haven't fully published their results yet, but they were able to show us what a bioprinted heart valve using their technique could look like. This, again, was printed with a hair gel, and it's based on an actual pig heart valve like this one down the line. Doctors [00:03:30] could use a technique like this to print the exact tissue they need on demand during surgeries. Something like this actually could be implanted in a human body in as little as five years. That's what the doctor just told me. Now, if you're wondering about a fully printed human heart, he says that's still a long way off. But what do you think about this technology? You find it exciting? Let me know in the comments below. If you enjoy this video, please don't forget to give it a thumbs up and subscribe to CNET for more what the future.

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