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Fortnite's big battle Friday will be against...cancer?

There's a slim chance Reese Witherspoon or Ken Jeong could show up too. (Like, the very slimmest chance.)

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Fortnite is the most popular game on Twitch this year by minutes watched. 

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Amazon's Twitch will live stream a special Fortnite competition on Friday that pits popular streamers Markiplier and Pokimane against each other to raise awareness of Stand Up To Cancer, a charity that is holding its star-packed television broadcast the same night. 

The stream of Fortnite, which is the most popular game on Twitch this year by minutes watched, will also try to wrangle appearances from celebrities attending the main telecast. Those stars include Reese Witherspoon, Ken Jeong, Matthew McConaughey, Keith Urban, Trevor Noah, Jennifer Garner, Tony Hale, Ed HelmsKarla Souza and many others. 

Mixing celebrities with Fortnite streaming has been a winning combo before. In March, a stream of rapper Drake playing the massively popular battle royale game with Ninja, one of the most popular Fortnite streamers on Twitch with 11 million followers. 

That stream broke Twitch's viewer record at the time, with a peak of more than 600,000 people watching at the same time. (Ninja broke Twitch's record again a month later playing Fortnite, hitting 667,000 concurrent viewers.)

The special Twitch stream will air from 4 pm to 6 pm PT on Friday, and will be hosted by Rachel "Seltzer" Quirico. The organizers want to raise awareness for Stand Up to Cancer's main telecast and encourage people to visit the charity's site, StandUpToCancer.org.