When you have a small business, you set up your own stuff a lot of the time--it's not worth the time and hassle to pay someone else to do it. Still, unless you're an expert, you may be terrified you're doing something wrong.
From CNET cousin TechRepublic comes a nice list of "10 things you should do to a new PC before connecting it to the Internet" (registration required). The link will take you to a page where you can download the free PDF.
Tips include a lot of obvious stuff, but it's great to have the list, which includes the following:
Some of the items just dejunk the machine, others have to do with security or performance. Take a look at the 10 and include your comments or additions to the list. Please.