Wine.com said Monday that it had lopped off 65 percent of its work force as part of a plan to streamline its business. The Napa, Calif.-based company confirmed that it laid off 160 out of 245 employees and also was revamping its executive staff. A decision on a final executive team had not been reached. Wine.com, which merged with WineShopper.com last August, continues to take orders. Besides grappling with a slowing economy, online liquor stores have faced regulatory obstacles regarding the sale and transportation of alcohol.