PowerToGo works with Windows 2000 SP4, Windows XP, and also the upcoming Windows Vista. Lexar's demonstration was done on a Vista machine, and it worked very well. Performance, of course, depends on the connection (preferably USB 2.0) and the speed of the drive itself. This is where Lexar comes into play. Its new premium JumpDrive product offers reading speed of up to 160X (24MB per second) and writing at 120X (18MB per second). At these speeds, there's no noticeable latency when you run software directly from the external drive.