Scientists Explain Why Our Brains Feel Tired After Thinking Really Hard

There could be a reason we can't eternally compute like a computer.

Monisha Ravisetti Former Science Writer
Monisha Ravisetti was a science writer at CNET. She covered climate change, space rockets, mathematical puzzles, dinosaur bones, black holes, supernovas, and sometimes, the drama of philosophical thought experiments. Previously, she was a science reporter with a startup publication called The Academic Times, and before that, was an immunology researcher at Weill Cornell Medical Center in New York. She graduated from New York University in 2018 with a B.A. in philosophy, physics and chemistry. When she's not at her desk, she's trying (and failing) to raise her online chess rating. Her favorite movies are Dunkirk and Marcel the Shell with Shoes On.
Monisha Ravisetti
3 min read
A man sits alone working at his desk in an office with rows upon rows of empty desks. It is probably nighttime.

At a certain point, our brains might become physically hampered from thinking.

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Recall a time you stared at your screen for 10 hours to finish a last-minute report for work, a 2,000-word essay on a book you never read, or any other sort of mental marathon. At the end of it all, you probably felt like you needed to dissociate from the world because your brain had turned to Jell-O. 

We call that feeling mental fatigue -- it's not that we feel sleepy, exactly, yet our minds are weak and it becomes really hard to do any more complex reasoning than we already have. If we tried to, we'd simply be unwell. 

Here's the good news.

This mushy brain sensation probably isn't merely in our heads. According to a study published Thursday in the journal Current Biology, prolonged, intense cognitive activity literally causes potentially toxic byproducts like an amino acid called glutamate to build up in our brains. These byproducts are thought to adjust our decision-making and provoke us to stop thinking so very hard and gravitate toward more relaxing, low-stress activities. And this might be the human body's way of protecting itself from burnout.

"Influential theories suggested that fatigue is a sort of illusion cooked up by the brain to make us stop whatever we are doing and turn to a more gratifying activity," Mathias Pessiglione of Pitié-Salpêtrière University in France, lead author of the study, said in a press release. "But our findings show that cognitive work results in a true functional alteration -- accumulation of noxious substances -- so fatigue would indeed be a signal that makes us stop working but for a different purpose: to preserve the integrity of brain functioning."

"Even professional chess players start making mistakes, typically after 4–5 hours in the game, which they would not make when well rested," the study authors write.

Pessiglione and fellow researchers arrived at their conclusion after studying two groups of people with a technique called magnetic resonance spectroscopy, which measures biochemical changes in the brain. The first group was given difficult cognitive tasks, like those involving stressful economic-related decisions. The second had to complete much easier activities, like identifying vowels and consonants with ample break time between each question.

The team's results showed that the group that had to think much harder indicated reduced pupil dilation and higher levels of glutamate in their brain's prefrontal cortex, the part that influences things like cognitive flexibility, attention, decision-making and impulse control. 

This then led the researchers to review other relevant brain scan data and eventually conclude that thinking superhard likely leads to glutamate accumulation in the brain, which makes it tougher for us to activate our prefrontal cortex, and therefore hampers our cognitive control and other prefrontal functions. Notably, however, the study warns against taking these findings as causative, stating "our results are only correlational and cannot be taken as proof that what limits cognitive control exertion is the need to prevent glutamate accumulation."

To confirm one way or another, further testing is required. "Nevertheless," the study writes, "glutamate regulation has been pointed out as an essential component in the brain energy budget and discussed as a potential source of cognitive fatigue."

OK, so what's the solution, you ask?

Unfortunately, according to Pessiglione, there isn't one, though the researcher offers that, "I would employ good old recipes: rest and sleep! There is good evidence that glutamate is eliminated from synapses during sleep." 

In other words, we might want to consider our mental activity the same way we'd consider our physical activity. To climb a mountain, it's usually best not to sprint, but rather steadily walk -- with some breaks for food, water and even a solid night's sleep.