ISO comparison
These are 100 percent crops taken from the center of our test scene. At small sizes, you can see that the photos are overly soft, even at the Sony Cyber-shot DSC-WX10's lowest sensitivity, ISO 100. Viewed larger, though, you can really see the lack of fine detail and noise, which just gets worse at higher ISOs. Of course, if you never do any cropping or enlarging and only make small prints and view photos at normal screen sizes, the photos will likely be good enough. However, because the WX10's overall results were not as good as Sony's other Exmor R-sensor cameras, it got a lower rating than models such as the WX9 and HX7V.
ISO 800 three ways
There are a few ways to take low-light shots with the WX10. In this example, I took shots using Intelligent Auto, Superior Auto, and the Handheld Twilight scene mode. All of these were taken at ISO 800. The Intelligent Auto mode only takes one shot, and while that resulted in more noise, it's also a bit sharper than the others. Superior Auto and Handheld Twilight are multishot modes, where the camera takes several shots and combines them into one photo with reduced noise and blur from hand shake. (More correctly, Superior Auto combines the Intelligent Auto mode with three multishot modes and the camera decides what's best to use.)
Regardless of method, if you're using the photos at small sizes and not heavily cropping them, all of them work well for capturing low-light subjects without a tripod or other support. However, all of the multishot modes require still subjects and shouldn't be used with anyone or anything moving.
Macro
The WX10 does well with close-ups, able to focus just 1.9 inches from a subject. The results are a little soft when viewed at full size, but you can tightly crop them and still get a good-looking photo. Plus, with the f2.4 maximum aperture you can get a shallow depth-of-field in macro.