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The D850's body remains relatively unchanged from the D810 but there are some notable enhancements.
Nikon's new Focus Shift capability is very similar to Olympus' Focus Stacking, though it doesn't combine the shots in-camera. You choose an increment or the number of shots, and it automatically focuses at varying distances. It saves the series of shots for postprocessing on a computer.
While the connections are all the same as on the D810, the D850 incorporates Wi-Fi and Bluetooth.
One of the nice enhancements is the tilting touchscreen.
Nikon punted the on-camera flash in order to improve dust and weather resistance.
The D850 graduates to XQD and SD cards from CompactFlash and SD.
It's not new to Nikon, but it is new to this line.
Nikon says it's made the grip deeper, but I didn't notice much of a difference.