No conversation with Mullenweg would be complete without a discussion of the WordPress antispam utility, Akismet -- a service inspired by the young developer's mother. I also find it interesting that while Mullenweg is an ardent booster of open-source development, Akismet is closed. Watch the interview to see why.
Other topics covered: the pressure of running a service that people make their living on, the relationship with Automattic CEO Tony Schneider, and the goodness of what "Web 2.0" stands for. Plus, Matt's favorite Web 2.0 sites and his tip for keeping multiple computers in sync.