Cambridge was the site of Anyday.com, an online calendar service company acquired by Palm in a cash and stock deal valued at $80 million when it was announced in May 2000. Palm has largely folded that effort into MyPalm, a portal for handheld users.
Palm laid off 500 workers in two rounds of job cuts earlier this year.
The latest cuts follow the resignation earlier this month of CEO Carl Yankowski, following a difficult year for the company, which suffered through a botched product launch and steep drop in demand that resulted in losses and a pileup of inventory.
Palm is looking to split into two separately traded public companies specializing in hardware and software.