This is an update of a post from many moons ago.
Mo' gadgets often means mo' problems--or, at least, mo' remotes. That's why I continue to champion Logitech's Harmony series of universal remotes, which not only take the place of multiple clickers but also let you set up crazy-handy macro functions.
One of the better models, the 650, usually sells for around $80. But if you don't mind going the refurbished route, you can get one for half the price. While supplies last, Ice Monkey has the refurbished Logitech Harmony 650 remote for $39.99 shipped.
In case you're not familiar with the Harmony line, Logitech's famed wizard-driven setup software makes them easier to program than most.(Note that I didn't say "easy," but rather "easier." Some aspects can be confusing.)
You simply choose your gear (TV, receiver, DVR, Blu-ray player, etc.) from a mammoth database, configure any one-button actions you want ("turn on TV, switch to input 4, turn on Xbox," etc.), and presto: you're good to go. The Harmony is also blissfully easy to use, with guided onscreen help in case something didn't turn on or switch modes or something.
The Harmony 650 features a color LCD, backlit controls, and support for up to five devices. Alas, it's not rechargeable, so you'll have to swap in a pair of AA batteries every couple months (though you can always use rechargeable batteries, of course).
Incidentally, Amazon has the remote for $60.99 new, a pretty sweet deal in itself if you're not keen on refurbished gear. The only real difference is the warranty: the refurb is backed for 90 days, versus one year for new.
On a personal note, I've had the same Harmony One (the Rolls-Royce of the series) for about three years, and it's humming along just fine. If you're still juggling multiple remotes, I think you'll find this $40 very well spent.
Bonus deal: I've never tried ShopRunner, but it sounds interesting. The service offers free two-day shipping, and free shipping on returns, for a growing number of stores (including Newegg, RadioShack, and PetSmart). An annual membership normally runs $79 (ouch), but right now you can get a one-year ShopRunner subscription for just $1. (Just make sure your mark your calendar for a year from now so you remember to cancel--assuming you want to.) If you've tried the service, talk it up in the comments.