Boot safe mode, head to the device manager and remove ALL the mice found there. Reboot and if the hardware is good, Windows will find and reinstall the mouse.
The ps/2 optical mouse on my office computer quit working. Actually it quit a couple weeks ago but started back up and worked for maybe two weeks. The curser was in the middle of the screen and it would not move. I rebooted still no luck. Later that day it started working. well today it would not work again. I tried another mouse (ps/2) and an older one with the ball and then finally a usb mouse. NOne of them would work. I rebooted a ton of times with no effect. I rebooted with the mouse not attached and the weird thing is taht the pointer still remained in the middle of the screen. I tried to uninstall the mouse driver but not sure if it uninstalled as the pointer is still in the middle of the screen. I ran virus scan and found nothing. I don't want to get IT involved unless I have to because I have allot of end of the month things coming up and they are slow slow slow. Please help... Thanks