Safe methods include, createing a manual restore point prior to making changes, useing disk cleanup utility is usually sufficent.
start> my computer> then right click the drive (usually C) after computer calculates space, ck Tempoary internet files & Tempoary files (if this is what your after) and OK. Followed you a error checking <SCAN> as well as a defragment (even if it says you dont need to defrag, run it anyways)
If you are refering to going to start> my computer> drive C> Windows> Temp> to empty contents of Temp folder, Id say your headed for trouble. Your question appears clear, what you are attempting to do and why isnt. Perhaps share what you are trying to achieve here.
If your trying to clear Temp Internet files via IE right click IE on the desktop> delete cookies> delete files> & clear history> and etc...
Hope this helps, post back with more info.
Also spybot works well depending on what the goal is in cleaning usage tracks and such.
Before I empty this please confirm I shouldn't not do so? It's just I emptied this folder before or one like it and got a system has recoverd from a serious error message!
xp home on a Compaq Presario
Regards - stupid question I know but I've forgotten what I did wrong with the last folder months ago