I really doubt it's going to provide you with any real benefit, but at the same time, it takes little to no effort to implement. You'd probably just be better off turning off any and all file and printer sharing functions on the sterile system, then turning it off except when needed. Can't infect a system with anything unless it's turned on.
I'm reimaging one of my home systems that I intend to use as a "sterile" system (I will visit very a very limited selection sites on it, such as banking sites). I'm considering establishing the network location as "Public" instead of "Home", rationale being this would help prevent cross infection from other computers on my home network if they get a worm or virus. I do have friends that come over and hop on my network sometimes and who knows what contamination their systems have. Is this being overly paranoid? Will it cause annoying problems for this sterile system or other systems in my home network? I don't intend to share anything on this system with other computers on my home network. Seems to me that this ought to be the recommended setting for any computer always ... you can always share files using a USB drive if you really need to. Thoughts? Again maybe I am being overly paranoid. Back in the day there used to be worms that would look for ways to hop from system to system over the network, maybe that's much much harder these days. I do have a router between the DSL modem and my home network and I do run Norton Internet Security on all my systems, before you ask Thanks!