When registry software is involved, it's impossible to predict what the outcome will be, except that it's far more likely to be negative than positive.
heres what i've done
from command line run as administrator the [winsat disk -seq -read c:\] command returns "unable to open drive or device. error: failed to properly assess the disk. the parameter is incorrect." almost instantly
chkdsk says the drive is clean
sfc /scannow says there are no integrity issues
tried terminating the indexing process, exiting comodo internet security, terminated comodo system cleaner.
tried running under the"administrator" account
tried cleaning out the datastore file under \windows\performance\winsat
updated my bios (very nerve-wracking mind you)
and my drivers were downloaded from the appropriate device manufacturers site.
specs(built the machine myself)
os:windows 7 x64
500gb hitachi sata hdd (running in AHCI mode)
4GB ddr2-800 memory
2.20ghz amd athlon x2 dual core processor
ati4350 512mb graphics card.
biostar a785ge motherboard
500watt power supply
pertinent background software(that didn't come with windows 7)
comodo internet security
comodo time machine(system restoring software)
comodo system cleaner(registry cleaning software)

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