The folders and files you highlighted are normal to see on a Windows install.

Maybe you were asking a different question like "How can I clean up space for a W10 upgrade?"

My thoughts are:

1. Turn off system restore, then turn it back on.
2. BACKUP AN IMAGE OF THIS DRIVE IN CASE THINGS GO BADLY.
3. Uninstall antivirus and any app you can.
4. Remove your files to backups. I've lost count of folk that have gigabytes of movies on their PC.

Good luck.