When I read ME in a computer forum I think of Windows ME (the version) and you might be asking if anyone has found a way to run something else on 10 or other.
As to the uninstall, I've yet to see this happen. Mind you that the office runs a tight ship with no infected PCs, banged up OSes and always can restore with backups or from restore media. The number of folk that have no backups seem to show up during these OS upgrade times.
I installed windows 10 on my hp desktop and found that ME was not compatible with the main genealogy program that I use so i decided to take it Off of my computer. MIstake!!!! when I did as they said to uninstall it it took out my OS so I had t ostart over.