Old CD/DVD drives tend to lose the ability to boot.
About the safe mode keyboard issue. That's usually when an older machine has PS/2 and the owner has some USB keyboard.
Fixes for that vary from a BIOS change to pulling out a PS/2 keyboard for the work required.
Bob
Im able to get the "press any key to boot from CD" message. When I do that it ask me if I want to start it in safe mode. When I attempt to start it in safe mode thats when my keyboard stops working. Sometimes it doesnt ask if I want to start in safe mode, it will just boot windows as normal when I "press any key". I have an older keyboard not a usb one.

Chowhound
Comic Vine
GameFAQs
GameSpot
Giant Bomb
TechRepublic