I generally do not suggest people using "Sleep". Rather I have them shut it down if possible. If you have a newer machine that has an SSD, then they boot so fast that sleep mode is generally not even needed anymore.
Sleep mode basically has one of a couple states: 1) it keeps power to the memory and lets everything else power down. 2) copies the contents of memory to the system drive, powers everything down, and then reloads it when you reactivate the system. This is also known as hibernate.
The problem with both these modes is that they literally resume where you left off, and in some cases (more often from hibernate) don't do so gracefully. I've built my own systems since 1992, and since the ability to sleep was introduced I have yet to have a system that recovers from sleep mode correctly, even the commercial ones I've bought. They always have "quirks". Even my current MSI gaming laptop commits graphical seppuku every time it tries to wake up from sleep mode.
Sleep mode also allows people to bypass system reboots. Sorry folks, but Windows NEEDS system reboots every once in a while to clear the crud out. If you're not ever actually rebooting the machine, the gremlins can accumulate and that's ...bad.
So, in short, if you have an SSD in your system, just use "Shut Down" instead. If not, at least reboot the system every few days, and I suspect your load times will get better.
You can also do a disk cleanup on your system drive and see if getting rid of junk on the system helps.
I have a computer, Windows 10, that I use about once a week or so. I leave it on in the interim and let it go to sleep. The problem is, when I need to use it, it takes forever to wake up from sleep, find updates, install them and do whatever it is it needs to do before I can use it. Often it goes on for 15 minutes before it is actually usable. Any suggestions how to speed this up? Or, at least let it update, etc. while it is sitting unused? Thank you!
Updated 3/15/19: Please see additional updates from Byron here:
--Submitted by: Byron Y. aka CNET username: BCY123