Or maker of Reason 9. They wrote so they know why CPU use increases. Games can hit 100% of CPU and GPU and the effect is lower frame rates but in your case you have some audio glitches. Ask the author or company about limits in their app.

I see the Seagate so be sure to check it's Smart Values 01 and 07 for issues. I find when 01 and 07 have high values (in the thousands) that it can cause issues like yours. The fix is to put in a drive without that issue. How do I get a report? I use Speccy (see https://www.piriform.com/docs/speccy/using-speccy/publishing-a-speccy-profile-to-the-web if you want forum members to check for you.)