I find a lot of folk blew up the file system on eSATA drives because the didn't eject the drive.
eSATA here is same speed as internal but does have some risk. Let's hope you know all about backup copies.
I have an external dual hard drive bay that I use to mount a couple of hard drives for storing/backing up music and movies and whatever. Been using it for a little over a year and it wasn't until just now that I decided to use the eSATA port/cable rather than USB 2.0. *** have I been doing.
I can literally transfer files now 12.5x faster. I've been wishing that this thing was USB 3.0 for so long because of how slow 2.0 is but little did I know I've had the ability to transfer even faster than 3.0
Long story short...using eSATA if you have the ability to. Unless of course you have the ability to use Thunderbolt. I don't have that luxury