Use your example drive B as the fastest C: drive. Then do whatever you want after that. There are so many variables in anyones systems now, you really have to play around abit to get what works for you. Also, you didn't mention if you had CD drives, but I further suggest you keep those HDs on the primary channel. For detailed info as many HD makers provide some insight into your quest, visit thier support websites and find the FAQ or help guide on the topic.

good luck -----Willy