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Sorry but you didn't supply the bare minimum for forum members to get a good view of this machine.
A wild guess is the machine's maker didn't install the proper mainboard drivers. But that's just a guess and likely wrong.
I bought an external harddrive enclosure for a WD 40gb HardDrive. It has an external power source. Plugged it into my Vista box. No go, it locks up Explorer almost instantly. When I try to start the computer with the harddrive on, Vista locksup, as soon as I turn the harddrive off, Vista resumes. I tried the harddrive on my XP box, and it runs flawlessly.
I'm going nuts guys, give me something I can work with here.