Don't upgrade to Vista until most of the driver issues are worked out. I'm currently running Vista and I'm currently having troubles with my webcam driver since Logitech isn't offering a driver for it yet for Vista. I'd wait a couple months for all the Vista drivers to be released and for software to be updated to officially support Vista.
I ran the the Vista Compatability test and it told me that my Microsoft IntelliType Pro 5.3 Keyboard (Ergonomic Keyboard 4000) might have minor compatability issues and also Symantec Winfax Pro 10;0 may have minor issues. I can't find any info on the sites regarding these 2 items (Ironically, one of the sites, of course, is Microsoft) and what to do. Do you know where I could find some answers - also McAfee Internet Security Suite - is that an issue? Thank you so much. don't want to install this if I'm going tofight with it. Running a AMD Athlon 64x2 Dual Core Processor 5000+

Chowhound
Comic Vine
GameFAQs
GameSpot
Giant Bomb
TechRepublic