I have no blockers installed but allow no SPYWARE and use Firefox or Mozilla most of the time.
If you allow SPYWARE on your machine, then no blocker known will stop such popups. The safe and free SPYWARE killers are at http://forums.majorgeeks.com/showthread.php?t=35407
In closing, if you use IE, then you will continue to leave the door open to common SPYWARE. It is that simple today.
Can using muliple pop up blockers work better or worse. Im using the blockers supplied with the new internet explorer sp2, google toolbar, ad-watch. And of course I still get some popups. Just wondered if anyone had any thoughts on the subject. Thanks.