My methods to delete such can use any below.
1. Boot safe mode and try again.
2. Look at ownership, and such then correct (you find folk unable to do this.)
3. Boot up another OS and delete them from there. I use a Linux boot USB stick for that.
I discovered some type of redirect associated with my Chrome browser that was placing LARGE files (about 50mb each) in my Temporary File Folder. This was causing the hard drive space to fill up quickly. I uninstalled Chrome and this appears to have stopped the file creation but I cannot delete the temporary files that have the extension either chrome_installer or chrome_updater. When trying to delete, I get a message that says that the file is running/in use by another program. Has anyone encountered this and how can I identify what is running so that I can kill that application then delete the files that total about 45gb of my hard drive?