I could imagine your IE has been hijacked !
You could try cwshredder:
Download and run: CWShredder (version 1.59.1)
Use the Fix button and follow the instructions you will receive.
My work got hit by a trojan and or spyware. PC's that got hit were Win 2K SP3 - SP4 PC's were ok. Was briefly briefed on issue. Dont have alot detailed information.
At this time all I have is this:
PC's got hit with some sort of popups.
IE does will not open,then program runs
spybot S&D and adaware found tons