As no known protection works against everything, why not go with what you like along with the usual self defense?
That is, those that depend on these protection apps usually get the worst infections.
Yesterday I had vtecksquad fix my computer by remote access. They disabled my Trend Micro Titanium Internet Securities and installed Microsoft Security Essentials. Which of the two anti-viruses is the best? I have been using Trend Micro for three years. It has detected trojan horses and viruses more than once. Opinions will be appreciated. Thanks Norman