Firstly, centrifugation is limited in that it generally is only effective with particles of different specific gravities and immiscible liquids. I'm not a chemist and didn't get past 2nd year college chemistry but I remember some properties that were useful in qualitative and quantitative analysis. One was the ability of some substances to bind with others and form precipitates that could be spun out in a centrifuge. Another was the ability of some chemicals to dissolve substances when some solvents could not. For a very long time, I've been wondering if such could be used to strip plaque from the vascular system. Obviously, it could be risky but what if one could be injected with a chemical in increments and subject to something similar to apheresis? Could the fatty stuff be turned into small globules that would easily pass through one's system but be separated by centrifugation?