Even if he removes the hard and plugs it into another same laptop, will he be able to do anything with all those defences - and most importantly, remain UNDETECTED?
Guys, just check that security strategy, that i believe will reduce the known odds of undetected intrusion to zero.
1. Setting strong windows password
2. Disable all USB/CD boots, enable Secure Boot on Uefi
3. Sets passwords to all your UEFI BIOS options
3. Encrypt the entire hard
4. Activate DisplayLastLogonInfo option from the registry (that way everytime you log in to your windows it will show you the last time you've been logged.
5. Everytime when you are logging in, check your Event Viewer and look when was you last Logoff (if you see logon in the time period you were out, you will know someone was in)
6. Only join the network directly from the cable (do not install router)
7. Buy a special lockable laptop bag..
Rubber Duckies and other types of Bad USB's will still be detected by the windows as logins, right? So i will know if someone used anything like that. With all those protective measures, is there any possible way that someone can install something on my laptop without leaving any trace? (When we exclude the 5 dollar wrench)
What do you think?

Chowhound
Comic Vine
GameFAQs
GameSpot
Giant Bomb
TechRepublic