Are you saying that there is an OS X system on both of those drives?
If that is the case, then there is no way around the "problem"
Why do you have things separated like that? All that software will live, reasonably happily, on the same drive and you can use one drive for the design storage and the other as the boot disk and applications folder.
What you have is not a usual arrangement for a machine with two drives in it which may explain why there is no mention of that particular configuration in most books.
P
Hi everyone. I hope each of you had a very happy Thanksgiving. I have a question to ask. I feel very embarrass for contacting you guys with so many questions that seem so simple. The user manual does not help in most cases. I have 2 hard drives on my G4 Power Mac. One is used for my graphic design, web design, and desktop publishing software. The other one is used for general computing browsing, e-mail, internet surfing, and using Virtual PC for windows files. If I am using the one for graphics and want to switch to the other to use Virtual PC, I have to open System Preferences and click on the name of the other drive and then restart in order to use that drive with its software. Are there any shortcuts I can use instead of going through so much trouble?

Chowhound
Comic Vine
GameFAQs
GameSpot
Giant Bomb
TechRepublic