One of the startup items creates the two temporary files and locks them. That's why you can't delete in normal mode. However, it could be a legit application/service that uses them.
Your first troubleshooting tool it's either msconfig or task manager whichever way you're comfortable with. In task manager, you kill some third party processes and try deleting the two temp files until you'll find the responsible. In msconfig, you disable some and isolate the cause.
There are other methods too, but you've got the idea.
Trying to unweave, unwind, unravel
And piece together the past and the future,
T. S. Eliot
Am using WinXP Pro SP1 along with AVG7 Free Edition, Spybot Search & Destroy, AdAware, SpySweeper, SpywareBlaster, Microsoft AntiSpyware Beta.
Have scanned for virus with online Panda Activescan, RAV Antivirus, Symantec and Housecall. Everything clear.
I suspect my system is somehow infected with some malware because :
a) Can delete all but one or two TMP file like ~DF1572, ~DFF186 in C:\Documents and Settings\username\Local Settings\Temp
On trying to delete get message "...is in use by another application and cannot be accessed." .
Even after using GiPo@MoveOnBoot at the next boot new files crop up
Even after deleting in Safe Mode on rebooting new files crop up.
Need expert help to solve my problem.