McAfee calls it: Adware-SubSearch.dr

First, once this item is in the Virus Chest do I need to do anything to further neutralize it? You only have to delete it from there.

Then browse to the C:\documents and settings\\User Name (repeat for all users)\local settings\temp folder and delete all files and folders in it.
Then browse to the C:\Windows\Temp folder and delete all files in it.
Then in internet explorer click tools>internet Options>General. Click on Delete Files make sure you get all offline content as well.

Then empty the recycle bin.

Then Disable system restore: Instructions here.


Finally, do an online scan using Trend Micro Housecall. It is available here.

Enable system restore again.