It would be wise to have 1 set of backups in your safe at home and another set stored off-site. Your offsite options might include a safe deposit box at the local bank, or, you could use a backup service like Carbonite. I have been using them for over 6 months and am pleased with the ease of use. You can use this link to download a free 15-day trial subscription to Carbonite, and get an extra free month of service when you buy: http://www.carbonite.com/raf/signup.aspx
You'll need a high speed internet connection, and the initial backup will take quite some time, so be prepared.