...scanned the computer for viruses and spyware? You can do it in Safe Mode, have you tried? Which antivirus and spyware removal tools do you have installed?
While in Safe Mode, please shut down all the unnecessary start up programs that are running in the background. Then clean out the junk files on the computer. Follow the steps in the links below:
For Windows 2000/XP, ignore the first couple of sentences about checking "resources" in the link below but follow the rest of the procedures including the "Services" links at the bottom.
How To Shut Down Unnecessary Start Up Programs
How To Clean Unwanted Files From The Hard Drive
After following all the procedures above, run Error Checking/Chkdsk and Defrag to optimize the hard drive:
How To Run 'Error Checking/Chkdsk' On Win2000/XP
Hope this helps and let us know how it goes.
Grif
I've no idea why this is happening but my computer will show the Windows Screen on start up but does not go beyond. I can start in Safe Mode. Interestingly, when I go to printers and fax - it shows that I have none at all. So I have no idea where to start. I have a Mind Computer AMD Athlon 64 Processor 3400+ 2.4GHZ processor Running Windows XP Home Edition. I sure would appreciate help as this is my business computer and can't work until it's fixed!! I also run a Samsung printer ML-1740 and Epson RX500 Photo. Tx

Chowhound
Comic Vine
GameFAQs
GameSpot
Giant Bomb
TechRepublic