As Roddy mentioned, try running your Spybot and Ad-aware in safemode. If that does not work, give Ewido a try:
1. Download Ewido security suite from http://download.ewido.net/ewido-setup.exe
2. After the download is complete, double click on the file to launch the install process.
3. During installation under the Additional Options menu, you will be asked if you want to ''Install background guard (required for automatic updates)'' and ''Install scan via context menu''. Please UNCHECK both of these options.
4. Once installation is complete, launch Ewido by double-clicking the big ''E'' icon on your desktop. The program will prompt you to update -- click the 'OK' button.
5. The program will now go to the main screen. On the left hand side of the main screen, click on Update and then click 'Start Update'. The update will start and a progress bar will show the updates being installed. After the updates are installed, you will see 'Update Successful' in the lower left corner.
Once the updates are installed do the following:
Please reboot into Safe Mode:
Turn on the computer.
Immediately begin tapping the F8 key (or F5 on some computers)
Use the arrow keys to highlight Safe Mode and press the Enter key.
When your computer is booted into Safe Mode, then continue.
6. Click on 'Scanner' (the 3rd bar from the top on the left) and Choose 'Settings'
7. Please make sure 'Scan Every File' is selected. Finally, please click 'OK'
8. On the main screen, please select 'Complete System Scan' and the scan should begin.
9. While the scan is in progress, you will be prompted to clean the first infected file it finds. Choose Remove, then put a check next to 'Perform action on all infections' in the the box. Doing this, enables the scan to proceed automatically until its completion. Click OK.
10. When the scan is complete, click ''Save Report''.
Your scan results will be saved in a textfile. You may need to refer to this later.
If Ewido ''crashes'' or ''hangs'' during the scan, try scanning again by doing this:
1. Scan one sector of the system at a time by using the ''Custom Scan'' feature. To do this select Scanner > Custom Scan and click on Add drive/directory/file. Browse to C:\Windows > System, add this folder to the list and click on ''Start Scan''. When the scan is complete, repeat the Custom Scan but this time, browse to and add the System32 folder. Then keep repeating this procedure until all your folders have been scanned. Make sure you include the Documents & Settings folder.
2. If this still does not help, then turn the ADS scanner off while making a Custom Scan. To do this select Scanner > Scan Settings and untick ''Scan in NTFS Alternate Data Streams''. Then repeat the steps above for performing a Custom Scan.
Note: Ewido is a free trial product for 14 days. Since Ewido is a trial version, the realtime guard and automatic update will stop functioning after 14 days that is why we are not installing the guard so it will not interfere with the cleanup or the malware removal process. You can use Ewido as an on-demand scanner (recommended) but you will have to manually update the definition file each time you scan. If you decide to purchase Ewido, you can enable the 'Realtime Protect' and 'Automatic Update' functions by clicking on the 'Status' bar (Top left) and clicking on both items under ''Your Security Status''.
If none of these steps resolve your problem, you might want to post a HijackThis log on one of the sites that handles them.