I'm having the exact same "robot audio" problem with HD channels on my LN40A450. Same scenario, direct connection to Comcast cable.
We have the TV plugged into a surge protector strip that we usually power off at night. So we had been essentially "unplugging" the TV every night.
I'm now trying the factory reset solution that has worked for some. I reset it last night (holding down the Exit button on the remote), and watched hours of election coverage in HD without any problems. I'm going to leave the power strip on for a week, and see if the audio stays good. Then I'll cut off the power, and see if the problem comes back. I'll report back with the result.
I hope that I've posted this question on the correct forum.
We just received and installed our new Samsung LN22A451 white TV in the bedroom on the wall. Service is Comcast, directly into the TV, not thru a set top box. After 2 days, we started get sound distortion, fluttering. We were watching HDTV channel at the time, and it happens on other HDTV channels as well. We returned that new TV and got a second new one, same model. We get sound distortion on that second TV as well. Could this be a Comcast signal problem? Could the problem be that we are not using a set top box on this new TV?
Our other HDTV in the living room, a 32" Toshiba uses Comcast but is thru a set top box. We've had no sound problem with that TV over 2 years. Any thoughts? Thanks, Pete M.

Chowhound
Comic Vine
GameFAQs
GameSpot
Giant Bomb
TechRepublic