What kind of anti-spyware and anti-virus are you running?
Did your computer came with Vista or did you up grade?
Which version of Vista do you have?(Home Premium, Ultimate)
Also please provide some more system information (like RAM, age of the computer)
Also your post some what confused me as it seems that you are not ending any of your sentiences. This is one from your post: "I have to let it sit for a little bit and when i come back it will." I did assume that the computer did came on after awhile. On your next post please finish your sentiences so we know what it is you are trying to say. I am not trying to be mean or anything of the sort, I just want to point that out to you.
Yeah kinda self-explanatory. My computer, which i'm running vista, will go into sleep mode and won't come back up. Also when i turn it off, it won't reboot. the power light comes on and the fan too, but the computer boot up. I have to let it sit for a little bit and when i come back it will. the computer will act like it is running something when nothing is being ran at times, in turn slowing it down. I have defraged it,did a disk clean, and ran a virus/spyware scan. I run ONECARE. Can anyone tell what the heck is going on?