Found the problem. Multifunction mouse controls had been changed. The scroll wheel on top made icons larger or smaller if held down. Go figure.
Home built w/ASUS MB, 4 gig RAM, Intel i5, WIN 7 64 bit, Nvidia G Force 8500, Viewsonic VA 2026 Monitor, Logitech MX600 cordless keyboard and mouse.
Today my wife was working with photos in Photoshop Elements and the screen started to go crazy. Icons on desktop are super large. Tried to change resolution but changes made icons only larger. Res now set at 1680 X 1050 and that is the smallest icons will go. All other software is proper size and resolution. Don't know anything else to try. Thanks in advance.