Parasite removal programs.
Nothing is revealed in your post that would be a clue. As such, I'll offer a generic advice that all pests be removed and that you try the machine with the cover off to see if the issue is heat. You also will check to see if update Video, Audio and Printer drivers are available and installed.
http://reviews.cnet.com/5208-6132-0.html?forumID=32&threadID=1313&start=0 notes the five scanning tools and removal tools that are fairly safe. If one does encounter an issue, its always been damage done by the MALWARE. The most common issue being Layered Service Provider replacement which you can use LSPFIX (Hint: use http://www.google.com to find).
The thread has follow on discussions about new links if you don't want to use Google to find an item.
PS. All the tools are free.
I have checked all the posts and not found exactly this one.
Using ME 4.90.3000,using a Pentium III 128.0MB and printer is Canon BJC 3000.
Only over last few months, screen(mouse etc) has increasingly been 'freezing' when the printer is switched on if required(not always on). Have to turn off printer, do an 'illegal' shutdown of PC, then reboot.Might or might not do it again....
Apart from this have never had any probs with ME which was installed from new.