I'm not familiar with Tweak now reg. cleaner.
Did it offer ot backup the registry before cleaning?
If so did you do the backup.
You should always backup the registry before making any changes to it.
Open the program to check if there is an option to restore or undo changes that were made. If so, restore or undo to see if it remedies the problem.
If you did backup the registry prior to cleaning, try to locate the file and restore from it. (usually double clicking the file will get the job done)
Best of Luck