Essentially, these programs are reliable, and it is safe to remove everything they propose. They offer a restore for when it needs to be recovered after all.
If you don't trust them, you'd have to do research about each item you've got doubts on. For some of those this forum may be helpful, but you've got to be specific.
Hope this helps,
How do you know what is safe to remove with adaware and spybot search & destroy.