Running My Computer runs My Computer while winkey+E runs Windows Explorer. I doubt if it is possible to change that.
Kees
Opening My Computer in WinXP-Pro/SP3 can result two possible presentations : double-clicking My Computer tends to open it with the left pane being headed by System Tasks, whereas Win E tends to show the pane with Folders.The steps of my macro to automate the launching of a checkdisk, requires there be no ambiguity. Is there a way of ensuring that Win E ALWAYS results in only the ONE (whichever) view being presented ?

Chowhound
Comic Vine
GameFAQs
GameSpot
Giant Bomb
TechRepublic