Personally I wouldn't.
There is no need to do anything in the registry as it is just a glorified database, and any unused entries just sit there, not doing any harm. Certainly with such a new OS as Windows 7 there should be no need for any optimisation or registry cleaning at this early stage, and I would suggest against ever touching the registry.
We see posts and discussions all too often in these forums where systems have failed after the user has used such utilities, and changes have been made to the registry that the OS could not recover from.
My advice, stay away from them and from the registry.
Could someone help me know about options for registry maintenance on my Windows 7 machine? I'm running W7 Pro 64-bit on an hp pavilion.
I used Uniblu on my XP machine which seemed to work well, and I use the registry clean-up utility in BitDefender on my W7 Pro machine now. Is that good enough to keep the registry in good form?