First thing you need to understand, is that drive letters are not in any way fixed or significant. When I first got into using computers in the Windows 3.1 days, D was generally used for optical drives. Mostly by convention, but the point is that drive letters can be wildly different between systems. Just because something is on the D: partition on your system, doesn't mean that's how it is on everyone else's system.
That all being said... MOST of the time, though you failed to give important details like the bit in red above where you entered your post suggested, a partition like that is used by the manufacturer to avoid having to ship reinstall CDs with a system. They just dump all the files from the CD onto a partition on the drive because it's cheaper. Assuming that's the case with your system, you shouldn't need to worry about this partition.
As for the rest... I have to say that of all the various utilities included with Windows, disk cleanup has got to be the single most pointless and useless of the entire lot. Pretty much all it does is delete anything in the recycle bin and IE cache directories.
The defragmenting program ranks a close second on the pointless and useless scale. It's a holdover from days long since past. Defragmenting of drives is no longer really necessary for the average user. If you're running a large database server, doing a lot of high end AV work, or even running a large web server... Anything that is considered disk intensive... It'd be a different story. But the majority of computer users spent the bulk of their time doing non-disk intensive things. Meaning that fragmentation levels have a negligible impact on performance. I'm sure others will disagree, and that's fine... Fact still remains that there are far more fruitful areas to spend your time and energy if you're looking to improve system performance, which is all that defragmenting could ever offer. Some people seem to have attached some kind of diagnostic and repair expectations onto it, which don't exist, and never have.
So, I suppose the long and short of things for you, is that you don't really need to worry about it at all. You can blissfully ignore the both of those things on any and all drives/partitions.
Sad but true. I cannot seem to get a straight answer for Disk Clean up and Defrag. In both, Disk Clean up and Defrag in windows xp; it
gives a choice for C and D hard drives. I have been told that a certain percentage would remain on the C drive due to factory installed proggams. (That I understand). But what about D drive?
My D drive is nearly filled up! Are those on D drive all factory
programs?? Do we all just forget about D drive?? Why am I given a choice,
if I am not to treat D drive the same as C drive when performing a disk clean up and defrag? You would think you were talking to the devil himself; when you talk about cleaning and defraging D drive.How about some straight answers out there.

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