The five tools I noted at http://reviews.cnet.com/5208-6132-0.html?forumID=32&threadID=1313&start=0 usually clear this up. If not, you can progress to other tools in that discussion.
Bob
hey, i was wondering if you could help me out if you know or have had the same problem, somehow http://www.quiksearchgenealogy.com/ keeps on making itself my homepage and everytime i click on internet explorer it also makes shortcuts on my desktop to 'diet pills' and 'play online' usually i can find the root of where they are but i have tried using spybot search and destroy and done many searches so now i turn here and was wondering if anyone could shed some light and help me out, Cheers!

Chowhound
Comic Vine
GameFAQs
GameSpot
Giant Bomb
TechRepublic